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l-Histidine is an essential amino acid that is not synthesized de novo in humans. Humans and other animals must ingest histidine or histidine-containing proteins. The biosynthesis of histidine has been widely studied in prokaryotes such as E. coli
Histidine is an amino acid; amino acids are used to make proteins and enzymes in the body. It is sometimes referred to as a “semiessential amino acid” because it is nonessential in adults, but essential in the diet of infants and those with a kidney disorder called uremia. Histidine is also called L-histidine and a-amino-b-[4-imidazole]-propionic acid.